Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor
Identifieur interne : 000102 ( France/Analysis ); précédent : 000101; suivant : 000103Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor
Auteurs : Maria Hovorakova [République tchèque] ; Jan Prochazka [République tchèque] ; Herve Lesot [France] ; Lucie Smrckova [République tchèque] ; Svatava Churava [République tchèque] ; Tomas Boran [République tchèque] ; Zbynek Kozmik [République tchèque] ; Ophir Klein [États-Unis] ; Renata Peterkova [République tchèque] ; Miroslav Peterka [République tchèque]Source :
- Journal of Experimental Zoology Part B: Molecular and Developmental Evolution [ 1552-5007 ] ; 2011-07-15.
English descriptors
- KwdEn :
- Anat, Anlage, Anterior, Anterior base, Anterior part, Apoptosis, Arrowhead, Biol, Biol peterkova, Black arrowhead, Body weight, Charles university, Cheek region, Craniofac genet, Czech, Czech republic, Dental epithelium, Dentition, Developmentally, Dimensional reconstruction, Earliest stages, Early development, Early stages, Embryo, Enamel, Enamel knot, Epithelial, Epithelial anlage, Epithelial bridge, Epithelial bridges, Epithelial swellings, Epithelium, Evol, Expression domain, Expression domains, Expression regions, Frontal histological sections, Frontal sections, Functional incisor, Grant sponsor, Histological, Hovorakova, Incisor, Incisor development, Incisor enamel organ, Incisor germ, Incisor region, Lamina, Large incisor placode, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower incisor area, Lower incisor region, Mandible, Mesenchyme, Molar, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse incisors, Mouse mandible, Munne, Mutant mice, Oral vestibule, Peterka, Peterkova, Placode, Prelacteal, Previous stage, Previous stages, Primordium, Proc natl acad, Prochazka, Quadrant, Reporter mice, Rudimentary, Rudimentary incisor, Rudimentary tooth, Sonic hedgehog, Thesleff, Tooth development, Tooth formation, Tooth morphogenesis, Vestibular, Vestibular epithelia, Vestibular epithelium, Vestibular lamina, Vestibule, Vonesch, White arrowhead, Zool.
- Teeft :
- Anat, Anlage, Anterior, Anterior base, Anterior part, Apoptosis, Arrowhead, Biol, Biol peterkova, Black arrowhead, Body weight, Charles university, Cheek region, Craniofac genet, Czech, Czech republic, Dental epithelium, Dentition, Developmentally, Dimensional reconstruction, Earliest stages, Early development, Early stages, Embryo, Enamel, Enamel knot, Epithelial, Epithelial anlage, Epithelial bridge, Epithelial bridges, Epithelial swellings, Epithelium, Evol, Expression domain, Expression domains, Expression regions, Frontal histological sections, Frontal sections, Functional incisor, Grant sponsor, Histological, Hovorakova, Incisor, Incisor development, Incisor enamel organ, Incisor germ, Incisor region, Lamina, Large incisor placode, Leica, Leica microsystems gmbh, Lesot, Lower incisor, Lower incisor area, Lower incisor region, Mandible, Mesenchyme, Molar, Morphogenesis, Mouse, Mouse embryos, Mouse incisor, Mouse incisors, Mouse mandible, Munne, Mutant mice, Oral vestibule, Peterka, Peterkova, Placode, Prelacteal, Previous stage, Previous stages, Primordium, Proc natl acad, Prochazka, Quadrant, Reporter mice, Rudimentary, Rudimentary incisor, Rudimentary tooth, Sonic hedgehog, Thesleff, Tooth development, Tooth formation, Tooth morphogenesis, Vestibular, Vestibular epithelia, Vestibular epithelium, Vestibular lamina, Vestibule, Vonesch, White arrowhead, Zool.
Abstract
For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer‐aided three‐dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild‐type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5–13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior–posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so‐called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. In the more advanced embryos, only this posterior Shh expression in the incisor bud was detectable as a precursor of the enamel knot. This study offers a new interpretation of published molecular data on the mouse incisor from initiation through ED13.5. We suggest that, as with Shh expression, other molecular data that have been ascribed to the progressive development of the mouse functional incisor at early stages, in fact, correspond to a rudimentary incisor whose development is aborted. J. Exp. Zool. (Mol. Dev. Evol.) 316:347–358, 2011. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jez.b.21408
Affiliations:
- France, République tchèque, États-Unis
- Alsace (région administrative), Bohême centrale, Californie, Grand Est
- Prague, Strasbourg
- Université de Strasbourg
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C33
- to stream Istex, to step Curation: 001C33
- to stream Istex, to step Checkpoint: 001465
- to stream Main, to step Merge: 004549
- to stream Main, to step Curation: 004521
- to stream Main, to step Exploration: 004521
- to stream France, to step Extraction: 000102
Links to Exploration step
ISTEX:39DDFF773901F2000D1FCAE1901308EBD4BC592ELe document en format XML
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centrale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</title><title level="j" type="alt">JOURNAL OF EXPERIMENTAL ZOOLOGY PART B: MOLECULAR AND DEVELOPMENTAL EVOLUTION</title><idno type="ISSN">1552-5007</idno><idno type="eISSN">1552-5015</idno><imprint><biblScope unit="vol">316B</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="358">358</biblScope><biblScope unit="page-count">12</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07-15">2011-07-15</date></imprint><idno type="ISSN">1552-5007</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-5007</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anat</term><term>Anlage</term><term>Anterior</term><term>Anterior base</term><term>Anterior part</term><term>Apoptosis</term><term>Arrowhead</term><term>Biol</term><term>Biol peterkova</term><term>Black arrowhead</term><term>Body weight</term><term>Charles university</term><term>Cheek region</term><term>Craniofac genet</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Developmentally</term><term>Dimensional reconstruction</term><term>Earliest stages</term><term>Early development</term><term>Early stages</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial anlage</term><term>Epithelial bridge</term><term>Epithelial bridges</term><term>Epithelial swellings</term><term>Epithelium</term><term>Evol</term><term>Expression domain</term><term>Expression domains</term><term>Expression regions</term><term>Frontal histological sections</term><term>Frontal sections</term><term>Functional incisor</term><term>Grant sponsor</term><term>Histological</term><term>Hovorakova</term><term>Incisor</term><term>Incisor development</term><term>Incisor enamel organ</term><term>Incisor germ</term><term>Incisor region</term><term>Lamina</term><term>Large incisor placode</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower incisor</term><term>Lower incisor area</term><term>Lower incisor region</term><term>Mandible</term><term>Mesenchyme</term><term>Molar</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse incisor</term><term>Mouse incisors</term><term>Mouse mandible</term><term>Munne</term><term>Mutant mice</term><term>Oral vestibule</term><term>Peterka</term><term>Peterkova</term><term>Placode</term><term>Prelacteal</term><term>Previous stage</term><term>Previous stages</term><term>Primordium</term><term>Proc natl acad</term><term>Prochazka</term><term>Quadrant</term><term>Reporter mice</term><term>Rudimentary</term><term>Rudimentary incisor</term><term>Rudimentary tooth</term><term>Sonic hedgehog</term><term>Thesleff</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth morphogenesis</term><term>Vestibular</term><term>Vestibular epithelia</term><term>Vestibular epithelium</term><term>Vestibular lamina</term><term>Vestibule</term><term>Vonesch</term><term>White arrowhead</term><term>Zool</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anat</term><term>Anlage</term><term>Anterior</term><term>Anterior base</term><term>Anterior part</term><term>Apoptosis</term><term>Arrowhead</term><term>Biol</term><term>Biol peterkova</term><term>Black arrowhead</term><term>Body weight</term><term>Charles university</term><term>Cheek region</term><term>Craniofac genet</term><term>Czech</term><term>Czech republic</term><term>Dental epithelium</term><term>Dentition</term><term>Developmentally</term><term>Dimensional reconstruction</term><term>Earliest stages</term><term>Early development</term><term>Early stages</term><term>Embryo</term><term>Enamel</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial anlage</term><term>Epithelial bridge</term><term>Epithelial bridges</term><term>Epithelial swellings</term><term>Epithelium</term><term>Evol</term><term>Expression domain</term><term>Expression domains</term><term>Expression regions</term><term>Frontal histological sections</term><term>Frontal sections</term><term>Functional incisor</term><term>Grant sponsor</term><term>Histological</term><term>Hovorakova</term><term>Incisor</term><term>Incisor development</term><term>Incisor enamel organ</term><term>Incisor germ</term><term>Incisor region</term><term>Lamina</term><term>Large incisor placode</term><term>Leica</term><term>Leica microsystems gmbh</term><term>Lesot</term><term>Lower incisor</term><term>Lower incisor area</term><term>Lower incisor region</term><term>Mandible</term><term>Mesenchyme</term><term>Molar</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse embryos</term><term>Mouse incisor</term><term>Mouse incisors</term><term>Mouse mandible</term><term>Munne</term><term>Mutant mice</term><term>Oral vestibule</term><term>Peterka</term><term>Peterkova</term><term>Placode</term><term>Prelacteal</term><term>Previous stage</term><term>Previous stages</term><term>Primordium</term><term>Proc natl acad</term><term>Prochazka</term><term>Quadrant</term><term>Reporter mice</term><term>Rudimentary</term><term>Rudimentary incisor</term><term>Rudimentary tooth</term><term>Sonic hedgehog</term><term>Thesleff</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth morphogenesis</term><term>Vestibular</term><term>Vestibular epithelia</term><term>Vestibular epithelium</term><term>Vestibular lamina</term><term>Vestibule</term><term>Vonesch</term><term>White arrowhead</term><term>Zool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For teeth as for any organ, knowledge of normal development is essential for the proper interpretation of developmental anomalies in mutant mice. It is generally accepted that tooth formation is initiated with a single signaling center that, in the incisor region, is exclusively related to the development of the functional adult incisor. Here, using a unique combination of computer‐aided three‐dimensional reconstructions and whole mount in situ hybridization of mandibles from finely staged wild‐type mouse embryos, we demonstrate that several Sonic hedgehog (Shh) expression domains sequentially appear in the lower incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5–13.5, we identified two spatially distinct regions of Shh expression that appear in an anterior–posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so‐called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. In the more advanced embryos, only this posterior Shh expression in the incisor bud was detectable as a precursor of the enamel knot. This study offers a new interpretation of published molecular data on the mouse incisor from initiation through ED13.5. We suggest that, as with Shh expression, other molecular data that have been ascribed to the progressive development of the mouse functional incisor at early stages, in fact, correspond to a rudimentary incisor whose development is aborted. J. Exp. Zool. (Mol. Dev. Evol.) 316:347–358, 2011. © 2011 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Bohême centrale</li><li>Californie</li><li>Grand Est</li></region><settlement><li>Prague</li><li>Strasbourg</li></settlement><orgName><li>Université de Strasbourg</li></orgName></list><tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Hovorakova, Maria" sort="Hovorakova, Maria" uniqKey="Hovorakova M" first="Maria" last="Hovorakova">Maria Hovorakova</name></region><name sortKey="Boran, Tomas" sort="Boran, Tomas" uniqKey="Boran T" first="Tomas" last="Boran">Tomas Boran</name><name sortKey="Boran, Tomas" sort="Boran, Tomas" uniqKey="Boran T" first="Tomas" last="Boran">Tomas Boran</name><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><name sortKey="Churava, Svatava" sort="Churava, Svatava" uniqKey="Churava S" first="Svatava" last="Churava">Svatava Churava</name><name sortKey="Hovorakova, Maria" sort="Hovorakova, Maria" uniqKey="Hovorakova M" first="Maria" last="Hovorakova">Maria Hovorakova</name><name sortKey="Hovorakova, Maria" sort="Hovorakova, Maria" uniqKey="Hovorakova M" first="Maria" last="Hovorakova">Maria Hovorakova</name><name sortKey="Kozmik, Zbynek" sort="Kozmik, Zbynek" uniqKey="Kozmik Z" first="Zbynek" last="Kozmik">Zbynek Kozmik</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterka, Miroslav" sort="Peterka, Miroslav" uniqKey="Peterka M" first="Miroslav" last="Peterka">Miroslav Peterka</name><name sortKey="Peterkova, Renata" sort="Peterkova, Renata" uniqKey="Peterkova R" first="Renata" last="Peterkova">Renata Peterkova</name><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><name sortKey="Prochazka, Jan" sort="Prochazka, Jan" uniqKey="Prochazka J" first="Jan" last="Prochazka">Jan Prochazka</name><name sortKey="Smrckova, Lucie" sort="Smrckova, Lucie" uniqKey="Smrckova L" first="Lucie" last="Smrckova">Lucie Smrckova</name><name sortKey="Smrckova, Lucie" sort="Smrckova, Lucie" uniqKey="Smrckova L" first="Lucie" last="Smrckova">Lucie Smrckova</name></country><country name="France"><region name="Grand Est"><name sortKey="Lesot, Herve" sort="Lesot, Herve" uniqKey="Lesot H" first="Herve" last="Lesot">Herve Lesot</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Klein, Ophir" sort="Klein, Ophir" uniqKey="Klein O" first="Ophir" last="Klein">Ophir Klein</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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